The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis, according to researchers. The study appears in Science Translational Medicine.

More than 40% of individuals will develop osteoarthritis (OA) during their lifetime. Hand OA is an extremely common form of OA, and there are currently no disease-modifying treatments that effectively relieve symptoms or stop deformity and stiffness of the joints.

“Hand osteoarthritis is a common and debilitating medical condition that affects mainly women, especially around the time of the menopause. We currently have no effective treatments that modify their disease,” says Tonia Vincent, Professor of Musculoskeletal Biology & Honorary Rheumatologist at Oxford’s Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS).

The researchers started by investigating a common gene variant that had been linked to severe hand OA. Using patient samples collected at the time of routine hand surgery, as well as a number of experimental models, they were able to identify a key molecule , called retinoic acid, that was especially low in “at risk” individuals.

“This project was only possible because of the multi-disciplinary approach that we took; working with our hand surgical colleagues, geneticists, data scientists and biologists,” Vincent adds.

As talarozole has an acceptable safety profile in human subjects, a small proof of concept clinical study is under way to see whether this drug might represent a new disease-modifying treatment in patients.

“Around 8.5 million people in the UK live with OA. Despite often being dismissed as just a few aches and pains, OA can have a profound and far-reaching impact on life, affecting people’s ability to work, care for a family, or live independently,” says Dr Neha Issar-Brown, Director of Research and Health Intelligence at the charity Versus Arthritis, which funded the research.

“There is an urgent need for disease-modifying treatments designed to prevent or reverse the painful symptoms of OA. This study reveals a new understanding of the causes of hand osteoarthritis, which could lead to identifying new biological targets for intervention in hand OA.

“This research is still at an early stage, but with these encouraging findings we are a big step closer in being able to develop a new class of disease-modifying drugs to treat osteoarthritis, prevent chronic pain, and enable people to live well with the condition,” Dr Issar-Brown concludes.

[Source(s): University of Oxford, EurekAlert]